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Design and Development of Novel Molecular Beacons for High-Precision T-Cell-Targeted mRNA and saRNA Delivery
Read moreLipid nanoparticles (LNPs) are delivery vehicles approved for nucleic acid delivery, notably mRNA, as used in COVID vaccines. Although mRNA is a…
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Jonathan Dorogin
Primary Applicant
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Fallopian Screening for Tubo-Ovarian Cancer: Early Detection with Optical Imaging and Lavage
Read moreThere are no effective screening tools for ovarian cancer, which is often found at late-stage. The most common and aggressive ovarian cancer…
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Jeanie Malone
Primary Applicant
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Improving brain health in brain injury survivors through partner-oriented research: Can cognitive training increase brain neurotrophins, reduce inflammation, and improve cognitive performance?
Read moreTraumatic brain injury (TBI) affects many Canadians and can lead to long-term cognitive deficits affecting an individual’s quality of life. Access to…
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Isla Shill
Primary Applicant
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Bidirectional genome-wide CRISPRi/a screening using ratiometric GCase substrates to identify genetic modulators of lysosomal GCase activity
Read moreParkinson’s disease (PD) is a progressive brain disorder in which lysosomes—the cell’s waste-clearing system—do not function properly, leading to toxic buildup that…
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Faezeh Jame-Chenarboo
Primary Applicant
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Co-creating mental health care from the ground up with autistic, AuDHD, and ADHD women
Read moreMasking involves social mimicry and emotional suppression, which autistic, AuDHD and ADHD (A3) women engage in higher levels due to societal expectations…
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Erika Ono
Primary Applicant
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Stress-induced intracellular amyloid aggregation as a novel mechanism of therapeutic resistance
Read moreMany cancers can form tumours that do not receive enough oxygen. This can lead to regions with low oxygen levels, and high…
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Emma Lacroix
Primary Applicant
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Applying a comparative effectiveness framework to evaluate perinatal outcomes of biosimilar versus originator biologic disease-modifying antirheumatic drugs
Read moreManaging rheumatic disease during pregnancy is challenging. Biosimilar medications, which are lower-cost versions of biologic drugs, have been shown in early studies…
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Dwayne Tucker
Primary Applicant
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Decoding cis-regulatory logic in Kaposiform Lymphangiomatosis to target NRAS-driven pathogenic endothelium
Read moreKaposiform Lymphangiomatosis (KLA) is a rare, life-threatening disease where abnormal lymphatic vessels grow throughout the body, causing bleeding disorders and fluid buildup…
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Dogancan Ozturan
Primary Applicant
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