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Development of Novel Alpha-amanitin Analogs for Targeted Cancer Chemotherapy
New toxins for incorporation into treatments known as antibody-drug conjugates are urgently needed to ensure therapeutic action.…
View details2020Competition
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Modulating microRNA-193a expression levels as a treatment for acute myeloid leukemia (AML)
Acute myeloid leukemia (AML) has a dismal prognosis in Canada with only every 5th patient surviving 5…
View details2020Competition
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Engineering the design of regulatory T cell therapy in transplantation
Transplantation is a cure for end stage organ failure, but a successful transplant requires a life-long use…
View details2020Competition
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Evolving Anxiety and Depressive Symptoms in Children Born Very Preterm: Brain, Stress Regulation and Parenting
Anxiety and depressive symptoms are the most common mental health problem in children born very preterm (24…
View details2020Competition
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Viral Determinants of Natural Human Cytomegalovirus Transmission
Cytomegalovirus (CMV) is a virus that is present in 50-90% of adults globally, depending on the region.…
View details2020Competition
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Bone Marrow Lesions in Osteoarthritis and Their Relation to Cartilage Contact and Stresses
One in eight Canadians suffers from osteoarthritis (OA), a debilitating joint disease that frequently includes bone bruises,…
View details2020Competition
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Using electronic medical record data and patient reported outcome measures to improve the early identification and management of knee osteoarthritis in Canadian primary care
Osteoarthritis is a painful joint disease and leading cause of disability that affects over 6 million Canadians.…
View details2020Competition
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Unraveling client selectivity and pattern recognition of J-Protein chaperones involved in preventing intracellular aggregation of polyglutamine peptides
Many neurodegenerative disorders are characterized by the accumulation of proteins forming toxic aggregates inside neurons. Certain proteins…
View details2020Competition
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Inheritors of the Future: Community-Driven Voices of Youth Contemplating Health and Wellbeing in Indigenous and Northern Geographies of British Columbia
Youth will inherit the decisions that are made today. Yet, youth in rural and remote northern and…
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Evolutionary mismatch: a cause of cardiovascular disease in industrialized societies?
In the Origin of Species, Charles Darwin presented that species evolved to best suit their environments. Endurance…
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Modifying brain activity on an individual basis to improve recovery after stroke
Impaired arm and hand function after stroke (~85% of stroke survivors in Canada) is linked to altered…
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Severity and Treatment of Menopausal Symptoms in Women Living with HIV
Globally, persons living with HIV are aging, with women constituting over half of this group. Increasingly, women…
View details2020Competition
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