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Regulating antibiotic resistance in Staphylococcus aureus: elucidation of the mechanism of BlaR1 through X-ray crystallography
The discovery of penicillin in the early 1900s offered the possibility of a “magic bullet” for the…
View details2004Competition
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Regulation and Function of Human T helper 17 Cells
Immune system homeostasis is determined by the balance between responses that control infection and tumour growth and…
View details2009Competition
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Regulation of anabolic metabolism in anti-tumour T cells
Our immune system protects of our body by detecting and destroying cells that are potentially cancerous. Sometimes,…
View details2022Competition
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Regulation of antibiotic resistance and virulence by two-component response regulators in Pseudomonas aeruginosa
The bacterium Pseudomonas aeruginosa is a major cause of hospital-acquired infections and chronic cystic fibrosis lung infections.…
View details2006Competition
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Regulation of Bcl-2 family members involved in macrophage cell survival
Shih Wei Wang is examining the role of a family of proteins implicated in atherosclerosis (hardening of…
View details2001Competition
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Regulation of energy balance in Stearoyl-CoA Desaturase-1 deficiency
Until recently, it was believed that the body burned fat only in response to hormones in the…
View details2004Competition
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Regulation of inhibitory receptor gene expression by Natural Killer cells
Natural Killer (NK) cells play an important role in the immune system: targeting and destroying tumour and…
View details2001Competition
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Regulation of innate epithelial response against A/E bacterial pathogens by TLR5 and single Ig IL-1R-related (SIGIRR) molecule
Bacterial infections in the intestine cause diarrheal disease worldwide, affecting people of all ages. These bacteria also…
View details2006Competition
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Regulation of intestinal homeostasis by colonic goblet cells in response to commensal and pathogenic bacteria
The gut lumen (interior space of the intestine) has developed to live in harmony with trillions of…
View details2008Competition
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Regulation of intestinal regeneration and cancer by the lysine methyltransferase Set7
Intestinal epithelial cells (IECs) form a protective covering over the small and large intestine. They are the…
View details2013Competition
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Regulation of lymphocyte activation and proliferation and synthesis of pro-inflammatory cytokines by the Caprin-1/G3BP-1 heteromeric complex
To fend off infections, our immune system has evolved effective strategies. These include rapidly increasing the number…
View details2007Competition
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Regulation of Rho GTPases by integrin-linked kinase
Cell surface proteins regulate interaction between cells and the material surrounding them called the extracellular matrix (ECM).…
View details2004Competition
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