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Elucidating how the Sotos Syndrome gene NSD1 controls gene expression during neuronal differentiation.
Each cell has the same genetic information, our DNA. Yet, our body consists of many different cell…
View details2024Competition
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Elucidating the effect of O-GlcNAc modification on protein stability
The glycosylation of proteins with O-GlcNAc is a ubiquitous post-translational modification found throughout the metazoans. Deregulation of…
View details2017Competition
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Elucidating the function of Bardet-Biedl Syndrome (BBS) proteins in Intraflagellar Transport (IFT)
Cilia are fine, hairlike projections that protrude from most cells of the human body. Many of these…
View details2007Competition
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Elucidating the functions of MCL-1 in DNA repair
Mammalian cells have developed elaborate DNA damage response (DDR) and DNA repair systems in order when to…
View details2011Competition
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Elucidating the molecular mechanisms underlying retinoid action in chondrogenesis
Musculoskeletal diseases represent the largest burden to the healthcare system and are major contributors to long-term disability…
View details2009Competition
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Elucidating the role of Fa2p in cilliary and cell cycle regulation
The majority of cells in the body contain a microscopic, hair-like organelle projecting from the cell surface…
View details2006Competition
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Elucidating the signal transduction pathways by which the host defence peptide LL-37 initiates immunomodulatory responses by bronchial epithelial cells
The immune system must strike a balance between fighting off illness and infection and damaging tissues in…
View details2007Competition
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Elucidation of the antibiotic resistance mechanisms of BlaR1 and MecR1 through structural, biochemical and cellular investigation using cell-free protein expression
The emergence of broad-spectrum antibiotic resistance is leading to the appearance of an increasing number of multi-resistant…
View details2011Competition
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Elucidation of the nature and biological importance of a novel calcofluor white-reactive surface polysaccharide of Campylobacter jejuni important in stress responses and in biofilm formation
Campylobacter jejuni (C. jejuni) is the leading cause of bacterial food poisoning. Infection with the bacteria leads…
View details2007Competition
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Emotion regulation among caregivers: Implications for psychological and physical health
Mounting evidence indicates that taking care of a spouse with a chronic disease increases the caregiver’s vulnerability…
View details2005Competition
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Endo-phenotyping of Asthma and Chronic Obstructive Pulmonary Disease Overlap by Airway Inflammation and Structure
Chronic obstructive pulmonary disease (COPD) and asthma are two different diseases that affect the airways. Around one-third…
View details2023Competition
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Endocrine mechanisms of bone mass and structural changes in prepubertal, over-and normal weight Asian and Caucasian boys: Associations with increased exercise and body composition
Based on her previous research on pediatric bone health, Dr. Kerry MacKelvie believes that perhaps the greatest…
View details2002Competition
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