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Truncation of huntingtin and its relationship to the pathogenesis of Huntington's Disease
Huntington disease (HD) is a fatal degenerative brain disorder caused by a defective gene, which causes cells…
View details2003Competition
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Tying the gut in knots: Characterizing how pathogenic E. coli transform the gut cell landscape
Diarrheal disease affects 1.7 billion people every year, killing around 760,000 children. A leading cause of this…
View details2018Competition
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Uncoupling dopamine and glutamine transmission in animal models of schizophrenia
Schizophrenia affects one per cent of Canadians — more than 300,000 people — causing personality and perceptual…
View details2003Competition
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Uncovering cytoplasmic domains of NMDA receptors important for basal and activity-dependent trafficking to synapses
Glutamate receptors are important for excitatory transmission between neurons and for basic neural function, and the NMDA-type…
View details2006Competition
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Uncovering how specific “STAC” proteins regulate muscle contraction
Skeletal and heart muscle contraction requires calcium ions. Calcium ions enter muscle cells through 'calcium channels', which…
View details2019Competition
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Uncovering metabolic mechanisms for tumor-driven immunosuppression with mass spectrometry imaging
Scientists have uncovered ways to turn the body’s natural immune system against cancer – an approach termed…
View details2024Competition
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Uncovering the role of long non-coding RNA PAN3-AS1 in acute myeloid leukemia
In Canada, Acute Myeloid Leukemia (AML) presents a significant challenge, with only a 30% five-year survival rate…
View details2024Competition
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Understanding adaptability in egg-laying behavior in Aedes aegypti
Mosquitoes are the deadliest animals on the planet. Aedes aegypti mosquitoes are found in many parts of…
View details2020Competition
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Understanding counsellor-client interactions in spinal cord injury exercise counselling: a novel method to explain outcomes of randomized controlled trials by assessing intervention fidelity
Behavioural interventions often consist of conversations between counsellors and clients and can be a successful way to…
View details2020Competition
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Understanding health equity and resource development (UnHEARD): New tools for assessing the health equity implications of unconventional natural gas development on rural and remote communities in northern British Columbia
Resource extraction and development activities are the primary drivers of social and economic development for communities across…
View details2016Competition
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Understanding low-income mothers' efforts to provide safe home environments for young children
Unintentional injuries represent the leading cause of death for children and youth under the age of 20.…
View details2003Competition
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