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Development of a patient-centred decision aid for rehabilitation in the advanced cancer setting
Advanced cancer and its treatment can lead to physical function declines and disability. Physical function is the…
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Population-Based Analysis of Nontuberculous Mycobacterial Pulmonary Disease in British Columbia
Nontuberculous mycobacteria (NTM) are a group of environmental bacteria, commonly found in the water and soil. Many…
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Developing TMEM119 as an attractive immunotherapeutic target in Osteosarcoma
With current treatment options patients with Osteosarcoma have a 5-year survival rate of about 76%, but for…
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Investigating the mechanisms underlying abnormalities in neuronal activity through human pluripotent stem cell-derived microglia-sufficient brain organoids in Huntington’s disease
Microglia are the immune defense cells located within the brain and also play a big role in…
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Effect of HPV integration on 3D genome structure and function in cervical cancer
In human cells, DNA is folded such that distant points on the linear genome may lie close…
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Structural and functional investigation of the skeletal muscle excitation-contraction coupling complex
This project aims to understand the basic function of the skeletal muscle, and how mistakes in this…
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Leveraging phage infection to decrease pathobiont virulence in inflammatory bowel disease
The makeup of bacterial communities in the gut is strongly linked with inflammatory bowel disease (IBD) including…
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New Connections Between Insulin and Exercise
Obesity and type 2 diabetes are significant public health issues, with 31% of British Colombians living with…
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Enhancing Immunomodulation by Novel Glycoconjugate-Based Organ Engineering to Prevent Transplant Rejection
Organ transplantation is a lifesaving therapy. In 2021, in Canada around 2,782 organ transplants were performed. Key…
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Spinal cord temperature as a measure of neuroinflammation in the human spinal cord
The lack of effective treatment options for neurological disorders underlines the critical need to identify new drug…
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Combatting infectious diseases through understanding epigenetic interference – A case study: SARS-CoV-2
Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has caused 6.5 M deaths globally. Despite currently available vaccines…
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Advancing understanding of the multiple sclerosis (MS) prodrome: a focus on understudied signs and symptoms (MS-Pro-Us)
Multiple sclerosis likely begins years before the first neurological symptom. During this period, it can present as…
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