Persons living with kidney disease may develop imbalances in gut bacteria, which in turn may produce substances (metabolites) that can increase inflammation, worsen health, and increase risk of kidney disease progression. We are conducting a study to assess the types of gut bacteria present in stool samples and types of metabolites in blood samples from people with kidney disease not on dialysis. We will include some people with normal nutritional status and some with a nutrition disorder called ‘protein-energy wasting’ that commonly occurs in kidney disease. This research program will assess the interactions between gut bacteria and metabolites in the blood, how they vary by nutritional status, and how they relate to kidney disease progression.
This work will help us develop personalized treatment strategies to improve nutrition in people with kidney disease, and to prevent progression to kidney failure. Throughout the research process, we have collaborated with 2 patient partners and consulted with the BC Renal Dietitians Committee. We plan to share study findings through publications, webinars and patient educational materials.